SERS of bovine serum albumin (BSA) proteins performed in liquid by optically trapping gold colloidal aggregates on which the protein is adsorbed. The enhanced BSA peaks are indicated: SS, disulfide bridges; Tyr, tyrosine; Trp, tryptophan, amide bands, stretching modes. The asterisks indicate the SERS signal from pyridine.
Reprinted with permission from Messina et al., J. Phys. Chem. C 115, 5115–22. Copyright (2011) American Chemical Society.